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. 2019 Oct 21;10(26):6511–6525. doi: 10.7150/jca.29931

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IL-6 augments the tumorigenic properties of osteosarcoma spheroids in vivo. (A) Representative images of primary osteosarcoma tumors. Control or IL-6-treated osteosarcoma cells were injected subcutaneously into nude mice. *P < 0.05 vs. control group. (B) Tumor growth curves. Tumor size and weight were measured after excision from mice (n = 5). *P < 0.05 vs. control group. (C-D) OPN and p-STAT3 levels in tumor tissues were measured by western blotting. Right panels, quantitative data. *P < 0.05 vs. control group.