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. 2019 Oct 22;10(26):6738–6746. doi: 10.7150/jca.35770

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The regulatory roles of lncRNAs in TAM epigenetics. LncRNA CCAT1 up-regulates PKCζ by decreasing the expression of miR-148a, resulting inhibiting M2 polarization, while down-regulate LncRNA CCAT1 have the opposite effect. Overexpression LncRNA NIFK-AS1 inhibits M2 polarization by reducing the expression level of miR-146a. LncRNA NEAT1 promotes proliferation and metastasis by inhibiting the expression of miRNA-214. LncRNA LNMAT1 promotes tumor lymphocyte metastasis and recruits macrophages through CCL2.