Table 4.
Univariate and multivariate Cox regression analysis for overall survival in patients with colon cancer
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | Pa | HR | 95% CI | Pa | |
| Gender | 0.522 | — | ||||
| Male | 1.00 | Reference | — | — | ||
| Female | 0.29 | 0.468-1.470 | — | — | ||
| Ageb (years) | 0.929 | — | ||||
| <60 | 1 | Reference | — | — | ||
| ≥60 | 0.929 | 0.600-1.751 | — | — | ||
| BMIb, kgm2 | 0.971 | — | ||||
| <18.5 | 1 | Reference | — | — | ||
| 18.5-23.9 | 0.916 | 0.312-2.690 | — | — | ||
| ≥24 | 0.937 | 0.531-1.653 | — | — | ||
| Locationc | 0.012 | 0.004 | ||||
| tumor height >12 cm | 1 | Reference | 1 | Reference | ||
| tumor height 6-12 cm | 1.081 | 0.209-3.721 | 1.080 | 0.595-1.961 | ||
| tumor height <6 cm | 1.176 | 0.6812.031 | 1.126 | 0.236-5.365 | ||
| Pathology (adenocarcinoma) | 0.005 | 0.002 | ||||
| Well differentiated | 1 | Reference | 1 | Reference | ||
| Moderately differentiated | 1.144 | 0.295-4.436 | 2.338 | 0.539-10.135 | ||
| Poorly differentiated | 1.879 | 0.583-6.054 | 3.647 | 0.332-1.260 | ||
| lymphatic/vascular invasion | 0.003 | 0.021 | ||||
| Yes | 1 | Reference | 1 | Reference | ||
| No | 0.441 | 0.257-0.758 | 0.647 | 0.3324-1.260 | ||
| PNI | 0.522 | — | ||||
| Yes | 1 | Reference | — | — | ||
| No | 0.831 | 0.473-1.462 | — | — | ||
| pT status | 0.042 | 0.012 | ||||
| pT1 | 0.389 | 0.114-1.329 | 0.158 | 0.015-1.617 | ||
| pT2 | 0.282 | 0.095-0.841 | 0.111 | 0.015-0.834 | ||
| pT3 | 0.759 | 0.038-1.702 | 0.840 | 0.340-2.076 | ||
| pT4 | 1 | Reference | 1 | Reference | ||
| pN status | 0.006 | 0.023 | ||||
| pN0 | 0.322 | 0.161-0.646 | 1.00 | Reference | ||
| pN1 | 0.605 | 0.313-1.168 | 0.523 | 0.240-1.141 | ||
| pN2 | 1.00 | Reference | 0.889 | 0.263-1.914 | ||
| pTNM stage | 0.003 | 0.015 | ||||
| Stage I | 0.373 | 0.180-0.773 | 0.735 | 0.352-0.916 | ||
| Stage II | 0.373 | 0.174-0.801 | 0.816 | 0.485-2.572 | ||
| Stage III | 1.00 | Reference | 1.00 | Reference | ||
| Smoking history | 0.069 | — | ||||
| Yes | 1.852 | 0.954-3.596 | — | — | — | |
| No | 1.00 | Reference | — | — | ||
| Drinking history | 0. 112 | — | ||||
| Yes | 3.738 | 1.347-10.370 | — | — | ||
| No | 1.00 | Reference | — | — | ||
| ABO blood type | 0.006 | 0.008 | ||||
| A | 0.832 | 0.416-1.666 | 0.760 | 0.365-1.582 | ||
| B | 0.368 | 0.165-0.823 | 0.356 | 0.155-0.819 | ||
| O | 0.299 | 0.128-0.699 | 0.282 | 0.114-0.694 | ||
| AB | 1 | Reference | 1 | Reference | ||
| Tumor size(cm) | 0.019 | — | — | 0.241 | ||
| <3.4 | 0.622 | 0.342-1.130 | 0. 673 | 0.343-1.323 | ||
| ≥3.4 | 1 | Reference | 1 | Reference | ||
| Serum CEA | 0.196 | — | ||||
| Normal | 0.701 | 0.409-1.201 | — | — | ||
| Elevated | 1 | Reference | — | — | ||
| CA19-9 | 0.038 | 0.956 | ||||
| Normal | 0.854 | 0.340-2.149 | 0.434 | 0.226-1.154 | ||
| Elevated | 1 | Reference | 1 | Reference | ||
| CA125 | 0.023 | 0.031 | ||||
| Normal | 0. 475 | 0.161-0.809 | 0.854 | 0.199-3.668 | ||
| Elevated | 1 | Reference | 1 | Reference | ||
Abbreviations: BMI=body mass index; 95% CI=95% confidence interval; HR=hazard ratio; pTNM stage=pathological tumour-node-metastasis stage.
a:Cox proportional hazards model.
b:Chinese definition.
c: NCOTARGET. 2015;6(34):36884-9.