Figure 3.

FOXO3a contributes to MHC II transcription by modulating histone modification. (a–g) RAW cells were transfected with small interfering RNA targeting FOXO3a or SCR followed by treatment with interferon‐γ (IFN‐γ) for 12 hr. ChIP assay was performed with anti‐acetyl histone H3 (a), anti‐trimethyl H3K4 (b), anti‐symmetrical dimethyl H3R2 (c), anti‐CBP (d), anti‐ASH2 (e), anti‐WDR5 (f), or anti‐PRMT5 (g). Data represent averages of three independent experiments and error bars represent SEM. *P ≤ 0·05.