Table 1.

Biodistribution of ⁹⁰Y-DOTA-GGNle-CyCMSH_hex on B16/F10 Murine Melanoma-Bearing C57 Mice

Tissues	0.5 h	2 h	2 h blockade	4 h	24 h
Percent injected dose/gram (% ID/g)
Tumor	20.73 ± 7.99	19.93 ± 5.73	1.20 ± 1.04a	14.8 ± 4.61	6.69 ± 1.85
Brain	0.10 ± 0.02	0.05 ± 0.03	0.03 ± 0.03	0.03 ± 0.02	0.03 ± 0.02
Blood	2.76 ± 0.69	0.36 ± 0.15	0.25 ± 0.12	0.22 ± 0.12	0.06 ± 0.07
Heart	1.28 ± 0.51	0.14 ± 0.10	0.13 ± 0.05	0.16 ± 0.09	0.11 ± 0.07
Lung	3.06 ± 1.05	0.42 ± 0.08	0.19 ± 0.12	0.27 ± 0.05	0.13 ± 0.15
Liver	0.99 ± 0.19	0.63 ± 0.14	0.39 ± 0.12	1.20 ± 1.34	0.60 ± 0.20
Skin	2.48 ± 1.05	0.78 ± 0.29	0.10 ± 0.12	0.53 ± 0.29	0.37 ± 0.18
Spleen	1.4 ± 1.36	0.24 ± 0.17	0.15 ± 0.12	0.31 ± 0.17	0.53 ± 0.42
Stomach	1.36 ± 0.4	0.87 ± 0.47	0.15 ± 0.06	0.61 ± 0.27	0.76 ± 0.52
Kidneys	12.68 ± 5.2	7.44 ± 1.85	4.99 ± 0.69	7.75 ± 1.59	5.23 ± 1.76
Muscle	0.73 ± 0.51	0.19 ± 0.13	0.10 ± 0.10	0.22 ± 0.31	0.15 ± 0.14
Pancreas	0.61 ± 0.43	0.18 ± 0.05	0.06 ± 0.07	0.14 ± 0.09	0.16 ± 0.14
Bone	1.37 ± 0.44	0.41 ± 0.18	0.15 ± 0.14	0.44 ± 0.34	0.2 ± 0.04
Percent injected dose (% ID)
Intestines	1.42 ± 0.38	0.57 ± 0.22	0.33 ± 0.15	1.36 ± 1.16	1.92 ± 3.51
Urine	75.42 ± 6.72	90.62 ± 1.79	96.77 ± 0.37	89.45 ± 4.25	93.01 ± 4.43
Uptake ratio of tumor/normal tissue
Tumor/blood	7.51	55.36	4.8	67.27	111.5
Tumor/kidney	1.63	2.68	0.24	1.91	1.28
Tumor/lung	6.77	47.45	6.32	54.81	51.46
Tumor/liver	20.94	31.63	3.08	12.33	11.15
Tumor/muscle	28.4	104.89	12.0	67.27	44.6

The data were presented as percentage injected dose/gram or as percentage injected dose (mean ± SD, n = 5).

^ap < 0.05 for determining significance of differences in tumor and kidney uptake between ⁹⁰Y-DOTA-GGNle-CyCMSH_hex with or without peptide blockade at 2 h postinjection.