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. 2018 Nov 5;14:1744806918815007. doi: 10.1177/1744806918815007

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Sequence alignment of DII/S3-S4 of Na_v1.7 from mammalian species. Schematic of a voltage-gated sodium channel showing the location of V810M and sequence alignment of DII/S3-S4 from Na_v1.7 orthologues from mammalian species. This region is highly conserved among orthologues of Na_v1.7 with only two variations, an isoleucine instead of valine in the rat at the position that corresponds to V810 in human Na_v1.7, and an alanine to serine in the S3-4 extracellular linker in bovine Na_v1.7.