Table 2.

Biophysical properties of WT and V810M channels following 30-min preincubation with either 30 µM CBZ or 0.1% DMSO vehicle control.

		Activation (mV)			Steady-state fast inactivation (mV)			Use dependence (20 Hz)
Nav1.7	Drug	V1/2	k	n	V1/2	k	n	Percent	n
WT	DMSO	–18.6 ± 0.8	8.2 ± 0.3	15	–87.3 ± 1.3	6.8 ± 0.2	15	78.5% ± 1.5	15
	CBZ	–20.2 ± 1.0	7.8 ± 0.2	12	–89.9 ± 1.5	7.1 ± 0.2	11	70.0% ± 1.7*	12
V810M	DMSO	–20.9 ± 0.5	7.8 ± 0.2	15	–87.8 ± 1.4	6.5 ± 0.2	14	77.1% ± 1.7	14
	CBZ	–21.5 ± 0.8	7.5 ± 0.3	13	–88.1 ± 1.9	6.8 ± 0.2	13	70.7% ± 1.6*	12

Note: CBZ: carbamazepine; DMSO: dimethyl sulfoxide.

*p < 0.01 significantly different from DMSO; n represents the number of cells from which recordings were acquired.