Table 1.
Phenotypes of Wt, Hri−/−, eAA, and Atf4−/− mice in ID
| Genotypes | ||||
|---|---|---|---|---|
| Wt | Hri−/− | eAA | Atf4−/− | |
| Phenotypes in ID | Wt | Universal knockout | Erythroid knockin of Ser51/Ala | Universal knockout |
| Viability | Normal | Normal | Normal | Perinatal Lethality |
| Anemia | Microcytic | Macrocytic | Macrocytic | Microcytic |
| Globin inclusion | No | Yes | Yes | No |
| Serum Epo | Low | Increased | Increased | Increased |
| BM erythropoiesis | Reduced | Ineffective | Ineffective | Ineffective |
| Spleen erythropoiesis | Enhanced | Ineffective | Ineffective | Ineffective |
| ROS erythroid | Low | Elevated | Elevated | Elevated |
| mTORC1 | Low | High | High | High |
BM, bone marrow.