Figure 3.
A. Concept behind the use of tumor pre-treatment with antibody-targeted photodynamic therapy (PIT) for improving nanoparticle delivery beyond the EPR effect. B. Fluorescence monitoring of Qdot800 accumulation in bilateral A431 subcutaneous xenografts administered one hour following right-flank treatment with Pan-IR700-mediated PIT. IR700: red, Qdot800: green. C. Histological analysis of intratumoral distribution of IR700 and liposomal daunorubicin (DX) one hour after drug administration, showing that PIT treatment increases extravasation distance and overall accumulation compared to traditional EPR-based delivery. D. Tumor growth inhibition was maximized using a combination of PIT pre-treatment and DX administration. E. Kaplan-Meier curves illustrating prolonged survival following combination treatment. Adapted with permission from 126, copyright 2013 American Chemical Society.