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A-485 inhibited activation of inflammatory pathways and inflammatory cell infiltration. (A) Western blotting was performed to validate the activation of NF-κB, MAPK and NLRP3 signaling pathways in RAW264.7 cells, liver tissues, and Ep300 knockdown RAW264.7 cells. (B) Immunohistochemical staining of macrophages (F4/80+) and neutrophils (LY-6G+) within liver tissue.
