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(A) Schematics showing the on-demand PEGylation and dePEGylation of nanocarriers via amphiphilic mPEG-TK-Ce6. (B) The PEGylation of TCNPPt efficiently prolonged the circulation time. Then, the dePEGylation of TCNPPt at the tumor site was achieved by cleaving the adjacent TK bond of mPEG-TK-Ce6 after irradiation to enhance cellular uptake.
