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Schematic illustration of the prodrug vesicles for improved cancer immunotherapy by combing ICD induction and CD47 blockade. (a) Schematic design of the dual-responsive, e.g., acidity and MMP-2 prodrug vesicles. (b) Simplified mechanism of NP-mediated chemo-immunotherapy and CD47 blockade, which inhibited tumor growth, distant metastasis, and relapse. Adapted with permission from 140, copyright 2019 John Wiley and Sons.
