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. 2019 Oct 22;9(26):8321–8331. doi: 10.7150/thno.35467

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Pten loss in Lgr5⁺ HFSCs promotes papilloma formation. (A) A schematic diagram of the two-step DMBA/TPA carcinogenesis assay. 3 weeks old Lgr5-CreER;Pten^flox/flox mice were treated with (Lgr5-Pten^-/-, n=8) or without (Lgr5-Pten^+/+, n=7) tamoxifen (TAM), followed by treatments with DMBA/TPA. (B) Skin tissues were harvested at different time points for histological analysis. HE staining of tissue sections showed changes of the skin. (C) The incidence of mice with skin papillomata. (D) The average number of papillomata per mouse in of the two groups. Scale bars, 100 μm. W, weeks.