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Pten loss in Lgr5+ HFSCs promotes SCC development. (A) Lgr5-Pten-/- mice and Lgr5-Pten+/+ mice were subjected to DMBA/TPA treatment, and the incidence of SCC in mice were examined. (B) Tumor tissues were harvested at different time points and subjected to histological analysis. HE staining of tissue sections showed invasion lesions. Lgr5-Pten-/- mice, n=8; Lgr5-Pten+/+mice, n=7. Scale bars, 100 μm.
