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. 2019 Oct 21;9(26):8253–8265. doi: 10.7150/thno.37351

Figure 6.

Figure 6

MSCs promote IL-27 production of dendritic cells through secreting IFN-β. (A) IL-27 produced by monocyte-derived DCs from SS patients (n=5) and HC (n=5). (B, C) IL-27 mRNA (B) and protein (C) of monocyte-derived DCs from HC with or without MSC treatment in the presence of 100ng/mL LPS was evaluated (n=5). (D) Genes related to IL-27 expression of DCs were screened and compared in MSCs co-cultured with and without monocyte-derived DCs from HC (n=4) in the presence of 100ng/mL LPS. (E) IL-27 mRNA expressions of monocyte-derived DCs with different concentrations of IFN-β treatment in the presence of 100ng/mL LPS (n=3). (F) IL-27 mRNA expressions of monocyte-derived DCs from HC co-cultured with MSC with and without IFN-β mRNA interference in the presence of 100ng/mL LPS (n=4). αMSC means siRNA silencing of IFN-β in MSCs. Data are presented as mean±SEM. Data were based on three independent experiments. *, p<0.05, **, p<0.01, ***, p<0.001.