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. 2019 Oct 17;9(26):8061–8072. doi: 10.7150/thno.37184

Figure 5.

Figure 5

In vivo evaluation of the therapeutic efficacy of cRGD-XIPs-Dox using B16 tumor-bearing mice. XIPs-Dox, cRGD-IPs-Dox, free Dox and PBS were used as controls. The drugs were administrated on day 0, 2, 4, 6 and 8 (5 or 10 mg Dox/kg). (A) Tumor volume changes. (B) Photographs of tumors collected on day 10. (C) Body weight changes. (D) Tumor inhibition rates on day 10. Data are presented as mean ± SD (n = 5). *p< 0.05, **p < 0.01, and ***p < 0.001 (one-way Anova and Tukey multiple comparisons tests).