Table 2.
Tissue procurement programs for the study of T1D pathogenesis in human pancreata 121.
| Tissue Procurement Programs and Biobanks | Cohort information | Initiatives | Reference |
|---|---|---|---|
| Network for Pancreatic Organ Donors (nPOD) | Transplant quality pancreas and lymphoid tissues collected from deceased organ donors at T1D onset to established disease, along with AAb+ donors and non‐diabetic corresponding controls. Samples are processed freshly at the University of Florida, banked, and distributed to hundreds of approved investigators around the world. | Investigate pancreas architecture and extracellular matrix in health and T1D pathogenesis | 42, 47 |
| Define autoreactive T and B cell repertoire and antigen specificities with an interest in therapeutic intervention | |||
| Investigate the role of viruses in T1D | |||
| Attain comprehensive ‘omics data | |||
| Examine pancreata from organ donors who received a pancreas transplant | |||
| Exeter Archival Diabetes Biobank (EADB) | Pancreata collected at autopsy from predominantly young patients with recent‐onset T1D | Identification of age‐dependent differential insulitic profiles | 43, 50, 71 |
| Investigate enteroviral infection as a possible trigger for T1D | |||
| Diabetes Virus Detection Study (DiVID) | Pancreatic biopsies from living patients with T1D | Investigate potential viral triggers for T1D | 44 |
| Human Pancreas Analysis Program (HPAP) | Transplant quality pancreas and lymphoid tissues collected from deceased organ donors at T1D onset to established disease, along with AAb+ donors and non‐diabetic corresponding controls. Samples are processed and subjected to comprehensive analyses at Vanderbilt University and University of Pennsylvania. Metadata are made available to investigators via a publicly accessible database. | Utilize novel technologies to profile immune and endocrine cells over the natural history of disease. | 45 |
| Human Atlas of the Neonatal Development and Early Life‐Pancreas (HANDEL‐P) | Transplant quality pancreas collected from control organ donors without diabetes ranging from prenatal to 10 years of age | Understand the early changes, whether structural, immunological, β‐cell‐centric or otherwise, that occur in the normal human pancreas, unaffected by diabetes | 122 |
*
AAb+ = Autoantibody positive; T1D = type 1 diabetes.