Table 2.
In‐silico functional analysis of TNFRSF1A mutations based on four different analysis tools
| AA change | SIFT | PROVEAN | PANTHER | PolyPhen2 | ||||
|---|---|---|---|---|---|---|---|---|
| G87V | Deleterious | 0·01 | Deleterious | −8.92 | Deleterious | −5.03 | Probably damaging | 1 |
| T90I | Tolerated | 0·19 | Deleterious | −4.647 | Deleterious | −4.19 | Probably damaging | 1 |
| T79M | Deleterious | 0·04 | Deleterious | −5.719 | Deleterious | −4.34 | Probably damaging | 1 |
| R121Q | Tolerated | 0·4 | Deleterious | −4.528 | Deleterious | −3.03 | Probably damaging | 1 |
AA = amino acid; SIFT = Sorting Intolerant From Tolerant; PROVEAN = (Protein Variation Effect Analyzer; PANTHER = Protein ANalysis THrough Evolutionary Relationships; PolyPhen‐2 = Polymorphism Phenotyping version 2.