Table 2.
Recently studied oncolytic adenovirus vectors.
| Vector name | Type of gene | Armed gene | Function | Promotor | Ad backbone | Target | Reference |
|---|---|---|---|---|---|---|---|
| Ad-sp-VGLL4 | Tumor-suppressor | VGLL4 | G2/M phase arrest; enhanced apoptosis | Survivin | Ad5 | HCC | (31) |
| Ha2bm-d19 | Transcription enhancer | a2bm; hypoxia-response elements (HRE) | Chimeric enhancer/silencer | AFP | Ad5 | HCC | (32) |
| Ad.wnt-E1A (Δ24bp)-TSLC1 | Tumor-suppressor | TSLC1 (tumor suppressor in lung cancer1) | Tumor suppressor gene which 5′ upstream region is methylated | E1A-Δ24bp | Targeting Wnt and Rb signaling pathway; cancer stem cell | (33) | |
| SG655-mGMP | 11R-P53; GM-CSF | 11R: penetrating peptide | hTERT; MCMV | Ad5 | Cancer stem cell; | (32) | |
| No name | miRNA | miR-122 | Negatively regulate virus replication | AFP | Ad5 | AFP-positive; miR-122deregulated cell | (34) |
| QG511-HA- Melittin | Cytotoxic gene | Melittin | Water-soluble toxic peptide | Hybrid promoter, hypoxia-response element (HRE)-AFP promoter | ZD55 | P53-deficient; AFP positive; | (35) |
| SG505-siFAK | Short-hairpin RNA | Hypoxia response element (HRE); siFAK | Against focal adhesion kinase (FAK) | hTERT; AFP promoter | SG505; Ad5 | HCC | (36) |
| ZD55-XAF1 | Increase sensitivity | XAF1 cDNA | Increase sensitivity | ZD55 | (1) | ||
| GD55 | Tumor targeting | GP73 | Target HCC cells | GOLPH2 promote | ZD55 | Liver cancer cells | (37) |
| AdCN305-SOCS1 | Tumor-suppressor | SOC1 gene | Negative regulator of STAT pathway | hTERT; deletion of CR2 region | HCC | (38) | |
| Ad-XAF-1&TNF-α | Tumor-suppressor | Ad-XAF-1&TNF-α | Inhibit proliferation | / | Ad5 | HCC | (39) |
| AD55-Mn-SOD | Tumor-suppressor | Mn-SOD gene | Cell toxicity | AFP | ZD55 | Liver cancer cells | (40) |
| SD55-TSLC1 | Tumor-suppressor | TSLC1 (tumor suppressor in lung cancer1) | Tumor suppressor gene which 5′ upstream region is methylated | Survivin | ZD55 | HCC | (41) |
| AFP-D55-SOCS3 | Tumor-suppressor | SOCS3 | Negative regulator of STAT pathway | AFP | ZD55 | AFP-positive | (42) |
| SG600IL-24 | Cytokine | IL-24 | Immune response modulator | TERTp; HRE | ZD55 | HCC | (43) |
| ADCN205 | Cytokine | miRNA-34a & IL-24 | Immune response modulator | Endogenous E3 promotor; hTERT for E1 | Ad5-Δ24 | HCC | (44) |
| Ad-ΔB/TRAIL | Cytokine | TRAIL | / | CMV promote E3 | Ad-ΔB | HCC | (45) |
| Ad-ΔB/IL-12 | Cytokine | IL-12 | / | CMV promote E4 | Ad-ΔB | HCC | (45) |
| SG511-CCL5-ODD | Chemokine | CCL5 | Attracts immunocytes; | hTERT promote E1a, hypoxia-response element (HRE)-AFP promote E1b | Ad5 | Tumor cell | (46) |