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. 2019 Nov 8;10:1287. doi: 10.3389/fphar.2019.01287

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Copyright © 2019 Wu, Wang, Lin, Shang, Wang, Zhou, Wang, Zhang, Luo and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CuC altered genes in HepG2 and PC-3 cells by RNA-Seq transcriptional profiling. (A) Differentially expressed genes in HepG2 and PC-3 cell response to CuC treatment. In HepG2 cells, there are 703 genes up-regulated and 358 genes down-regulated upon CuC treatment compared with control cells. For PC-3 cells, 465 genes show up-regulation and 184 genes shows down-regulation. (B) 91 genes affected by CuC were found in both HepG2 and PC-3 cells. (C) Gene Ontology analysis of CuC-responsive genes in HepG2 and PC-3 cells. PI3K-Akt signaling pathway, microRNAs, and cytokine–cytokine receptor interaction pathways are both significantly changed in both two cells lines.