Table 1.
Clinical, hormonal, metabolic, and oxidative stress parameters in PCOS patients and control women.
| Controls (n = 535) | PCOS (n = 654) | P | Pa | |
|---|---|---|---|---|
| Age (years) | 28.15 ± 4.15 | 25.00 ± 4.21 | 0.000 | |
| BMI (kg/m2) | 21.12 ± 2.86 | 23.24 ± 4.27 | 0.000 | |
| Waist circumference (cm) | 73.67 ± 8.38 | 80.00 ± 11.42 | 0.000 | 0.000 |
| Waist-to-hip ratio | 0.81 ± 0.06 | 0.85 ± 0.07 | 0.000 | 0.000 |
| F-G score | 0.25 ± 0.73 | 1.74 ± 2.06 | 0.000 | 0.000 |
| Acne grade score | 0.14 ± 0.35 | 0.65 ± 0.91 | 0.000 | 0.000 |
| SBP (mmHg) | 112.93 ± 11.48 | 114.84 ± 10.72 | 0.004 | 0.976 |
| DBP (mmHg) | 73.72 ± 8.86 | 75.79 ± 8.94 | 0.000 | 0.042 |
| AOV (ml) | 7.65 ± 2.89 | 10.11 ± 4.09 | 0.000 | 0.000 |
| Hormonal levels | ||||
| TT (nmol/L) | 1.51 ± 0.53 | 2.35 ± 0.77 | 0.000 | 0.000 |
| SHBG (nmol/L) | 54.59 ± 27.16 | 35.12 ± 26.84 | 0.000 | 0.000 |
| FAI | 3.40 ± 2.11 | 9.78 ± 7.07 | 0.000 | 0.000 |
| LH/FSH | 1.25 ± 1.25 | 2.30 ± 1.28 | 0.000 | 0.000 |
| Metabolic profile | ||||
| Fasting Ins (pmol/L) | 63.82 ± 35.26 | 106.01 ± 72.79 | 0.000 | 0.000 |
| Fasting Glu (mmol/L) | 5.24 ± 0.47 | 5.36 ± 0.86 | 0.002 | 0.900 |
| HOMA-IR | 2.23 ± 1.30 | 3.81 ± 3.09 | 0.000 | 0.000 |
| TG (mmol/L) | 1.04 ± 0.88 | 1.44 ± 1.39 | 0.000 | 0.000 |
| TC (mmol/L) | 4.25 ± 0.71 | 4.43 ± 0.82 | 0.000 | 0.000 |
| HDL-C (mmol/L) | 1.51 ± 0.32 | 1.38 ± 0.34 | 0.000 | 0.002 |
| LDL-C (mmol/L) | 2.36 ± 0.63 | 2.57 ± 0.76 | 0.000 | 0.000 |
| Oxidative stress parameters | ||||
| TOS (nmol H2O2 Equiv./mL) | 11.24 ± 5.32 | 14.92 ± 10.77 | 0.000 | 0.000 |
| T-AOC (U/ml/min) | 14.50 ± 2.69 | 15.80 ± 3.06 | 0.000 | 0.000 |
| OSI | 0.80 ± 0.41 | 0.99 ± 0.79 | 0.000 | 0.000 |
| MDA (nmol/ml) | 3.66 ± 1.07 | 4.34 ± 1.31 | 0.000 | 0.000 |
Values are presented as mean ± SD.
AOV, average ovarian volume; BMI, body mass index; DBP, diastolic blood pressure; FAI, free androgen index; F-G score, Ferriman–Gallwey score; FSH, follicle-stimulating hormone; Glu, glucose; HDL-C, high-density lipoprotein cholesterol; HOMA index, homeostatic model assessment of insulin resistance; Ins, insulin; LDL-C, low-density lipoprotein cholesterol; LH, luteinizing hormone; MDA, malondialdehyde; OSI, oxidative stress index; SBP, systolic blood pressure; SHBG, sex hormone-binding globulin; T-AOC, total antioxidant capacity; TC, total cholesterol; TG, triglycerides; TOS, total oxidant status; TT, total testosterone.
Pa, All comparisons of parameters were corrected for differences in age and BMI between the 2 groups except the parameters of age and BMI.