Table 3.
Frequencies of combined genotypes of GPx1 P198L and CAT C-262T, GPx1 P198L and SOD2 A16V, and CAT C-262T and SOD2 A16V in patients with PCOS and the control women.
| Genotype combinations | Controls (n = 535) | PCOS (n = 654) | OR | 95%CI | P |
|---|---|---|---|---|---|
| GPx1 P198L and CAT C-262T* | |||||
| PP/CC | 458 (85.6%) | 530 (81.0%) | 1.00 | – | – |
| PL+LL/CC | 41 (7.7%) | 84 (12.8%) | 1.745 | 1.128–2.701 | 0.012 |
| PP/CT+TT | 32 (6.0%) | 32 (4.9%) | 0.828 | 0.468–1.464 | 0.516 |
| PL+LL/CT+TT | 4 (0.7%) | 8 (1.2%) | 1.665 | 0.438–6.331 | 0.454 |
| GPx1 P198L and SOD2 A16V** | |||||
| PP/VV | 384 (71.8%) | 417 (63.8%) | 1.00 | – | – |
| PL+LL/VV | 39 (7.3%) | 61 (9.3%) | 1.333 | 0.829–2.145 | 0.236 |
| PP/AV+AA | 106 (19.8%) | 145 (22.2%) | 1.300 | 0.943–1.791 | 0.109 |
| PL+LL/AV+AA | 6 (1.1%) | 31 (4.7%) | 5.774 | 2.243–14.863 | 0.000 |
| CAT C-262T and SOD2 A16V*** | |||||
| CC/VV | 393 (73.5%) | 452 (69.1%) | 1.00 | – | – |
| CC/AV+AA | 106 (19.8%) | 162 (24.8%) | 1.421 | 1.039–1.942 | 0.028 |
| CT+TT/VV | 30 (5.6%) | 26 (4.0%) | 0.745 | 0.404–1.376 | 0.347 |
| CT+TT/AV+AA | 6 (1.1%) | 14 (2.1%) | 1.880 | 0.652–5.423 | 0.243 |
Data of genotype combinations are presented as number (%) of patients or controls.
Chi-squared test: x2 = 9.558, P = 0.023. Odds ratio (OR) and 95% confidence interval (CI) were calculated in a multinomial logistic regression model including age and BMI as covariates, the PP/CC combined genotypes (wild-type) as the reference category.
Chi-squared test: x2 = 17.416, P = 0.001. OR and 95% CI were calculated in a multinomial logistic regression model including age and BMI as covariates, the PP/VV combined genotypes (wild-type) as the reference category.
Chi-squared test: x2 = 7.742, P = 0.058. OR and 95% CI were calculated in a multinomial logistic regression model including age and BMI as covariates, the CC/VV combined genotypes (wild-type) as the reference category.