Table 5.
Controls | PCOS | |||
---|---|---|---|---|
CC | CT+TT | CC | CT+TT | |
(n = 499) | (n = 35+1) | (n = 614) | (n = 38+2) | |
Age (years) | 28.20 ± 4.07 | 27.44 ± 5.15 | 25.05 ± 4.24 | 24.33 ± 3.70 |
BMI (kg/m2) | 21.14 ± 2.88 | 20.84 ± 2.59 | 23.25 ± 4.26 | 22.97 ± 4.40 |
Waist circumference (cm) | 73.82 ± 8.37 | 71.46 ± 8.34 | 80.10 ± 11.44 | 78.41 ± 11.28 |
Waist-to-hip ratio | 0.82 ± 0.06 | 0.80 ± 0.06 | 0.85 ± 0.07 | 0.84 ± 0.07 |
F-G score | 0.24 ± 0.67 | 0.47 ± 1.32 | 1.73 ± 2.06 | 1.93 ± 2.14 |
Acne grade score | 0.15 ± 0.37 | 0.00 ± 0.00a | 0.64 ± 0.90 | 0.83 ± 0.96 |
SBP (mmHg) | 113.07 ± 11.48 | 110.79 ± 11.50 | 114.82 ± 10.72 | 115.26 ± 10.69 |
DBP (mmHg) | 73.73 ± 8.71 | 73.55 ± 8.00 | 75.68 ± 8.83 | 77.44 ± 10.41 |
AOV (ml) | 7.58 ± 2.72 | 8.27 ± 4.39 | 10.05 ± 3.96 | 11.13 ± 5.82 |
Hormonal levels | ||||
TT (nmol/L) | 1.50 ± 0.53 | 1.66 ± 0.53 | 2.35 ± 0.78 | 2.36 ± 0.74 |
SHBG (nmol/L) | 54.61 ± 27.57 | 54.37 ± 20.03 | 34.81 ± 27.07 | 40.07 ± 22.67 |
FAI | 3.42 ± 2.15 | 3.14 ± 1.51 | 9.89 ± 7.08 | 7.99 ± 6.76 |
LH/FSH | 1.27 ± 1.27 | 1.10 ± 0.81 | 2.31 ± 1.30 | 2.11 ± 0.91 |
Oxidative stress parameters | ||||
TOS (nmol H2O2 Equiv./mL) | 11.17 ± 5.30 | 12.14 ± 5.49 | 14.85 ± 10.65 | 16.16 ± 12.56 |
T-AOC (U/ml/min) | 14.54 ± 2.75 | 13.97 ± 1.77 | 15.77 ± 3.09 | 16.13 ± 2.62 |
OSI | 0.80 ± 0.41 | 0.88 ± 0.37 | 0.99 ± 0.80 | 1.00 ± 0.69 |
MDA (nmol/ml) | 3.66 ± 1.08 | 3.64 ± 1.02 | 4.35 ± 1.28 | 4.21 ± 1.76 |
Values are presented as the mean ± SD.
AOV, average ovarian volume; BMI, body mass index; DBP, diastolic blood pressure; FAI, free androgen index; F-G score, Ferriman–Gallwey score; FSH, follicle-stimulating hormone; LH, luteinizing hormone; MDA, malondialdehyde; OSI, oxidative stress index; SBP, systolic blood pressure; SHBG, sex hormone-binding globulin; T-AOC, total antioxidant capacity; TOS, total oxidant status; TT, total testosterone.
Comparisons of all parameters were corrected for differences in age and BMI between the 2 subgroups except the parameters of age and BMI.
P < 0.05, compared with the CC genotype subgroup in controls.