Table 1.
Patient and Disease Characteristics
| Characteristic | Statistic | RISC Data Set (n = 1082) |
San Raffaele Data Set (n = 1021) |
P |
|---|---|---|---|---|
| Median Age (Range), Years | 66 (32–93) | 68 (35–91) | .001 | |
| Male Sex, n (%) | 852 (78.7) | 853 (83.6) | .005 | |
| Smoking status | <.001 | |||
| Current smoker | 275 (25.4) | 148 (14.5) | ||
| Former smoker | 416 (38.5) | 289 (28.3) | ||
| Never smoker | 296 (27.4) | 133 (13.0) | ||
| Missing | 95 (8.8) | 451 (44.2) | ||
| Race | <.001 | |||
| Asian | 13 (1.2) | 0 (0) | ||
| Black | 40 (3.7) | 0 (0) | ||
| Hispanic | 15 (1.4) | 0 (0) | ||
| White | 995 (92.0) | 1021 (100) | ||
| Not stated | 7 (0.7) | 0 (0) | ||
| Other or mixed races | 12 (1.1) | 0 (0) | ||
| Ethnicity | <.001 | |||
| Hispanic or Latino | 85 (7.9) | 0 (0) | ||
| Other | 997 (92.1) | 1021 (100) | ||
| Median Charlson Comorbidity Index Score (Range) | 2 (0–13) | 1 (0–11) | <.001 | |
| Histology | <.001 | |||
| TCC | 802 (74.1) | 703 (68.9) | ||
| TCC with variants | 106 (9.8) | 196 (19.2) | ||
| Other (pure variant) | 120 (11.1) | 122 (12.0) | ||
| Missing | 54 (5.0) | 0 (0.0) | ||
| Clinical T stage | – | |||
| In situ, 0, 1 | 73 (6.7) | Not collected | ||
| 2 | 654 (60.4) | |||
| 3, 4 | 266 (24.6) | |||
| Missing | 89 (8.3) | |||
| Clinical N stage | – | |||
| 0 | 651 (60.2) | Not collected | ||
| 1 | 66 (6.1) | |||
| 2, 3 | 57 (5.3) | |||
| Missing | 308 (28.4) | |||
| Pathologic T stage | .089 | |||
| In situ, 0, 1 | 220 (20.4) | 211 (20.7) | ||
| 2 | 222 (20.5) | 178 (17.4) | ||
| 3 | 456 (42.1) | 421 (41.2) | ||
| 4 | 184 (17.0) | 211 (20.7) | ||
| Pathologic N stage | <.001 | |||
| 0 | 665 (61.5) | 625 (61.2) | ||
| 1 | 174 (16.1) | 112 (11.0) | ||
| 2 | 219 (20.2) | 241 (23.6) | ||
| 3 | 24 (2.2) | 43 (4.2) | ||
| Neoadjuvant Chemotherapy, Yes, n (%) | 316 (29.2) | 27 (2.6) | <.001 | |
| Adjuvant Chemotherapy, Yes, n (%) | 247 (22.8) | 155 (15.2) | <.001 | |
| Neoadjuvant or Adjuvant Chemotherapy, Yes, n (%) | 543 (50.2) | 179 (17.5) | <.001 | |
| Number of Lymph Nodes Removed | <.001 | |||
| 0 | 17 (1.6) | 11 (1.1) | ||
| 1–9 | 295 (27.3) | 129 (12.6) | ||
| >10 | 715 (66.1) | 881 (86.3) | ||
| Missing | 55 (5.1) | 0 (0.0) | ||
| Surgical Margins Positive, n (%) | 139 (12.9) | 98 (9.6) | .019 |
Abbreviations: RISC = Retrospective International Study of Invasive/Advanced Cancer of the Urothellum; TCC = transltional-cell carcinoma.