Table 2.

Univariable and Multivariable Logistic Regression Analyses for Exclusive Locoregiona Relapse Pattern (n = 1082)

		Univariable Analyses		Multivariable Analyses
Characteristic	Statistic	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
Age/Decade		1.02 (1.01, 1.03)	.002
	Male vs. Female Sex	0.84 (0.65, 1.09)	.19
Smoking Status			.15
	Current smoker	Reference
	Former smoker	0.80 (0.60, 1.05)
	Never smoker	1.01 (0.76, 1.36)
	Missing	0.75 (0.46–1.20)
Charlson Comorbidity Index, Continuous		1.08 (1.03, 1.13)	<.001
Histology			.014		.013
	TCC	Reference		Reference
	TCC with variants	1.04 (0.70, 1.55)		1.16 (0.78, 1.72)
	Variant	1.58 (1.16, 2.16)		1.49 (1.09, 2.04)
	Missing	0.60 (0.28–1.28)		0.48 (0.23, 1.02)
Pathologic T Stage			<.001		<.001
	<2	Reference		Reference
	2	2.15 (1.38–3.34)		1.74 (1.12, 2.72)
	3, 4	4.22 (2.88–6.18)		3.48 (2.37, 5.13)
Pathologic N Stage			<.001
	0	Reference
	1	1.27 (0.93–1.73)
	2–3	1.74 (1.34–2.26)
Positive vs. Negative Surgical Margins		2.34 (1.76–3.09)	.018	1.78 (1.33, 2.36)	<.001
Number of Lymph Nodes Removed			.023
	0	Reference
	1–9	0.74 (0.38–1.48)
	≥10	0.60 (0.31–1.17)
	Missing	1.05 (0.49–2.27)
Perioperative Chemotherapy, Yes vs. No		0.48 (0.38, 0.60)	<.001	0.47 (0.38, 0.60)	<.001

Abbreviation: TCC = transitional-cell carcinoma.