Figure 3.

Bacterial survival in reconstituted whole blood with sera from complement‐deficient patients or controls. Sera were collected from three patients with a late terminal complement pathway (LTP def.); C6 deficiency (○) or C8 deficiency (Δ and □) or two patients with alternative pathway deficiency (AP def.); factor I deficiency (○) or factor D deficiency (□) before (filled symbols) and after (open symbols) vaccination with multi‐component meningococcal serogroup B (MenB)‐4C. Clearance of the bacterium in whole blood reconstituted with patient sera (a) or heat‐inactivated patient sera (b) was determined. Results with a P‐value of < 0·05 were considered significant and are marked with an asterisk. Pre‐vaccination titers were compared between groups. The same was performed for post‐vaccination titers.