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. 2019 Aug 25;74(12):3565–3572. doi: 10.1093/jac/dkz357

Figure 2.

Figure 2.

Aciclovir concentrations in serum (n=32) and CSF (n=34) samples from patients (n=21) treated with aciclovir for herpesvirus CNS infection. (a) Increased CSF:serum albumin ratio, interpreted as an indication of BBB damage, is associated with increased aciclovir CSF concentrations. The dotted vertical line represents the upper normal reference for CSF:serum albumin ratio (10.2). (b) Decreased creatinine clearance, calculated using the Cockcroft–Gault formula, is associated with increased aciclovir serum and CSF concentrations. (c) Increasing dose of aciclovir is associated with increased aciclovir serum and CSF concentrations.