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. 2019 Nov 14;20:183. doi: 10.1186/s12881-019-0918-4

Table 2.

Allele and genotype frequencies of SLCO1B1 in patients taking aspirin

Gene Allele frequencies p† value for HWE Control
n = 250(%)
Case
n = 286 (%)
p Genotype Control
n = 125 (%)
Case
n = 143 (%)
p
SLCO1B1 A = 0.28 78 (31.2) 74 (25.9) 0.172 AA 9 (7.2) 10 (7.0) 0.947
388 A > G G = 0.72 172 (68.8) 212 (74.1) AG 60 (48) 54 (37.8) 0.091
rs2306283 P† = 0.44 GG 56 (44.8) 79 (55.2) 0.088
SLCO1B1 T = 0.79 180 (72.0) 245 (85.7) <0.001 TT 73 (58.4) 111 (77.6) 0.001
521 T > C C = 0.21 70 (28.0) 41 (14.3) TC 34 (27.2) 23 (16.1) 0.027
rs4149056 P† = 0.37 CC 18 (14.4) 9 (6.3) 0.028

p values from the Chi-squared test. †, Hardy–Weinberg equilibrium (HWE) of allele frequencies at individual loci was assessed by comparing the observed and expected genotype frequencies