Fig. 3.

Pathway and target analysis of miR-21, miR-146a, and miR-146b. a Visualization of the significantly associated GO biological processes using REVIGO. The semantic similarity-scatterplot shows the cluster representatives after the redundancy reduction. The bubble size indicates the frequency of the GO term and the color indicates the log₁₀ (adjusted p value). Color legend is shown in the left corner of the panel b: microRNA-target interaction network generated by Cytoscape software. Targets with strong experimental evidence for miR-21, miR-146a, and miR-146b were retrieved from miRTarBase [20]. Blue-colored targets correspond to those targets shared by miR-21 and miR-146a; pink-colored targets corresponds to those targets shared by miR-146a and miR-146b; yellow-colored targets corresponds to those targets shared by the three deregulated miRNAs