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. 2019 Nov 14;19:294. doi: 10.1186/s12935-019-1017-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Downregulation of miR-346 in glioma tissues and cell lines. a qRT-PCR analysis of miR-346 expression in normal brain tissues (NBTs, n = 10) and glioma tissues (n = 255). b qRT-PCR analysis of miR-346 expression in NBTs (n = 5) and glioma specimens (n = 15) divided according to WHO pathological classification criteria into grade II (n = 5), grade III (n = 5), and grade IV (n = 5). c FISH analysis of miR-346 expression in glioma specimens. d qRT-PCR analysis of miR-346 expression in normal human astrocytes (NHAs) and five glioma cell lines (U87, LN229, A172, U251, U118). *P < 0.05, **P < 0.01, ***P < 0.001