Table 3.

Geometric mean (95% confidence interval (CI)) from mixed-effect regression models, stratified by median of thelarche, menarche, and thelarche-to-menarche tempo in relation to percent dense breast volume (%DBV)

	Number	Mean (95% confidence interval)	p value
Thelarche effect
Early menarche/short tempo	62	15.73 (14.3–17.30)	Reference
Early menarche/long tempo	29	18.84 (17.05–20.81)	0.01
Late menarche/short tempo	29	21.33 (18.99–23.97)	< 0.001
Late menarche/long tempo	62	20.88 (17.49–24.92)	< 0.001
Menarche effect
Early thelarche/short tempo	29	20.47 (16.18–25.91)	Reference
Early thelarche/long tempo	62	19.81 (17.49–22.44)	0.82
Late thelarche/short tempo	62	16.34 (14.64–18.23)	0.11
Late thelarche/long tempo	29	20.40 (16.52–25.20)	0.98

The means and 95% confidence intervals are generated from stratified models including the same covariates included in model 3 of Table 2. The following variables were adjusted as fixed effects: adult covariates, including parity (nulliparous vs parous), duration of hormone use (years, continuous), education (some college or less (reference), bachelor degree, graduate degree), race (white vs. non-white), smoking status (never vs ever), and whole-body percent fat measured by DXA (%, continuous), height (continuous), and BMI at 8–10 years of age expressed as a z-score relative to CDC 2000 Growth Charts. Clinic was adjusted for as a random effect