Fig. 5.

Sensitivity of HR-deficient cell lines to cytotoxic agents. a Results of cytotoxicity measurements shown as the fold difference in sensitivity to the indicated drugs of each mutant cell line as compared to the wild type. The mean relative IC₅₀ values and SEM of three independent measurements are shown. The mean absolute IC₅₀ value of the wild type line is shown for each drug. b, c Correlation of the relative IC₅₀ values of cisplatin vs. carboplatin (b) and olaparib vs. talazoparib (c). Each marker represents a cell line, color coded as in a; the wild type is shown in black. The r² value for simple linear regression is shown. d Colony survival assay following the treatment of the indicated cell lines with cisplatin for 1 h. The mean survival percentages and SEM of three independent measurements are shown