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. 2019 Nov 15;19:1114. doi: 10.1186/s12885-019-6153-8

Table 4.

Association of Overall Survival and Recurrence Free Survival with Demographics and Disease Characteristics

Factors N Overall Survival (Months) Recurrence Free Survival (Months)
Median (95% CI) p-value* Median (95% CI) p-value*
Overall 232 44.0 (39.7, 49.9) 26.3 (20.9, 38.0)
Age at Diagnosis < 0.001 < 0.001
 < 60 130 52.2 (45.0, 84.9) 0.18^ 38.0 (22.3, 49.9) 0.26^
 ≥60 102 36.8 (25.1, 41.8) 22.0 (15.3, 26.6)
Pathologic Stage < 0.001 < 0.001
 I/II 68 Not reached < 0.001^ Not reached < 0.001^
 III/IV 140 38.0 (30.1, 41.8) 20.0 (16.6, 24.2)
Silberberg’s Grade < 0.001 < 0.001
 1 27 Not reached 0.23^ Not reached 0.060^
 2 or 3 205 41.8 (37.9, 45.9) 24.2 (19.1, 29.9)
Persistent Disease < 0.001 < 0.001
 No 144 69.8 (52.2, 85.7) < 0.001^ 35.8 (20.9, 51.4) 0.69^
 Yes 88 24.2 (15.3, 30.5) 24.2 (15.3, 30.5)
LHR-I 0.28 0.27
 Negative/Weak/Moderate 80 51.2 (40.7, 65.9) 29.9 (19.0, 46.0)
 Strong 152 41.9 (38.0, 45.3) 24.5 (19.6, 38.0)
LHR-P 0.36 0.53
 ≤ 50% 34 50.3 (35.4, 74.3) 36.0 (19.0, 50.3)
 >  50% 197 43.8 (39.2, 49.5) 24.6 (20.0, 38.0)

*p-value based on logrank test

^ p-value based on Wald test from Cox proportional model, adjusted by all other variables with p < 0.05 in univariate analysis