Table 1.
The roles played by S1P agonists and antagonists
| S1P modulators | Targets | Cancer models | Functions |
|---|---|---|---|
| S1P agonists | |||
| Fingolimod (FTY720) | S1PR1, S1PR3, S1PR4, S1PR5 | Lewis lung carcinoma [56], colon cancer [57], hepatocellular carcinoma [58], prostate cancer [59], multiple myeloma [60] | Suppressing angiogenesis [56], suppressing tumor growth and metastasis [57, 59], suppressing aggressiveness [60], inducing apoptosis [58] |
| AUY954 | S1PR1 | Unknow yet | |
| KRP-203 | S1PR1 | Unknow yet | |
| SEW2817 | S1PR1 | Unknow yet | |
| Siponimod | S1PR1 | Unknow yet | |
| Ponesimod | S1PR1 | Unknow yet | |
| S1P antagonists | |||
| TY52156 | S1PR3 | Unknow yet | Promoting tumor aggressiveness [67] |
| JTE-013 | S1PR2, S1PR3, S1PR4 | Unknow yet | |
| CYM-5478 | S1PR2 | Oral squamous cell carcinoma [67] | |