Table 2.

Roles played by individual S1PRs in different cancer

S1PRs	Cancers
S1PR1
Promote invasion and angiogenesis [19, 21, 81]  Promote progression [57, 75]  Promote migration and invasion [71–73, 76]  Promote invasion [77]  Promote survival and migration [78–80]	Breast cancer [19, 21, 71–73] Mice B16 tumor [75] Colon cancer [57] Wilms tumor [76] Glioblastoma [77] Fibrosarcoma [79] Hodgkin lymphoma [80]
S1PR2
Pro-tumorigenesis
Promote growth and invasion [82]	Cholangiocarcinoma [82]
Promote angiogenesis and growth [11]	Wilms tumor [11]
Promote invasion [83]	Glioma cell U-118 [83]
Promote migration and invasion [84]	Pancreatic cancer [84]
Promote lung metastasis [85]	Bladder cancer [85]
Increase drug resistance [66, 87]	Chronic myeloid leukemia [87]
Anti-tumorigenesis
Suppress migration [88, 89]	Glioblastoma cells [88, 89]
Suppress invasion [90]	Thyroid cancer C643 cells [90]
Suppress proliferation [12]	Wilms tumor [12]
Lead to diffuse B-cell lymphoma formation [91]	S1PR2 knockout mice [91]
Promote invasion [93]	Repress S1PR2 expression in esophageal squamous cell carcinoma [93]
S1PR3
Promote progression [95–97]	Breast cancer [95–97]
Promote migration [98]	Nasopharyngeal carcinoma cells [98]
Promote proliferation [102]	Osteosarcoma cells [102]
Promote growth [99–101]	Human lung adenocarcinoma cells [99–101]
S1PR4
Promote invasion and aggressiveness [105, 106]	Breast cancer cells [105, 106]
S1PR5
Pro-tumorigenesis
Promote survival [108]	Prostate cancer cells [108]
Anti-tumorigenesis
Suppress proliferation and migration [109]	Esophageal squamous cell carcinoma cells [109]