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. 2019 Nov 14;16:218. doi: 10.1186/s12974-019-1598-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Behavioral analysis and survival. Tempol treatment delayed body weigt loss (a) and improved motor performance in the Rotarod test (b) compared to SOD1^G93A mice treated with vehicle or riluzole. Each point in the graphs represents the mean ± SEM. Data were analyzed by two-way ANOVA for repeated measures, followed by a post hoc Bonferroni test. Treatment with tempol showed no significant change in survival (c) compared to SOD1^G93A mice treated with vehicle. The results were evaluated with the log-rank test p = 0.5088. *** vs NTG, ### vs vehicle (p < 0.0001); && vs riluzole (p < 0.001)