Table 2.
Prevalence, severity and frequency of current schizophrenia symptoms
| TRS (n = 408) |
Non-TRS (n = 204) |
p-value | |
|---|---|---|---|
| Positive symptoms | |||
| Experiencing any, % (n) | 84.6 (345) | 64.2 (131) | < 0.001 |
| Delusions | 50.7 (207) | 35.3 (72) | < 0.001 |
| Hallucinatory behavior | 46.1 (188) | 24.5 (50) | < 0.001 |
| Conceptual disorganization | 24.3 (99) | 17.2 (35) | 0.046 |
| Excitement or agitation | 11.8 (48) | 9.8 (20) | 0.47 |
| Hostility or aggression | 11.5 (47) | 4.9 (10) | 0.008 |
| Severity, mean (SD)a | 3.0 (1.0) | 2.5 (1.0) | < 0.001 |
| Experienced on a daily basis, % (n) | 27.5 (95) | 9.2 (12) | < 0.001 |
| Negative symptoms | |||
| Experiencing any, % (n) | 73.3 (299) | 61.8 (126) | 0.004 |
| Blunted affect | 37.0 (151) | 30.9 (63) | 0.14 |
| Emotional withdrawal | 35.8 (146) | 26.5 (54) | 0.021 |
| Social withdrawal | 30.1 (123) | 21.6 (44) | 0.025 |
| Poor rapport | 16.2 (66) | 14.2 (29) | 0.53 |
| Severity, mean (SD)a | 3.0 (1.0) | 2.4 (0.9) | < 0.001 |
| Experienced on a daily basis, % (n) | 45.5 (136) | 20.6 (26) | < 0.001 |
| Cognitive symptoms | |||
| Experiencing cognitive dysfunction, % (n) | 37.3 (152) | 24.0 (49) | 0.001 |
| Severity, mean (SD)a | 3.0 (1.0) | 2.5 (0.9) | 0.002 |
| Experienced on a daily basis, % (n) | 61.2 (93) | 36.7 (18) | 0.003 |
aSeverity rated 1 (minimal), 2 (mild), 3 (moderate), 4 (moderate–severe), 5 (severe), or 6 (extreme), for those patients experiencing symptoms
SD standard deviation; TRS treatment-resistant schizophrenia
p-values in bold are < 0.05