Figure 7.

Effect of Escherichia coli pneumonia with or without high-molecular-weight hyaluronic acid (HMW HA) administration on inflammation and pulmonary arterial pressure, airway pressure, and Po₂ levels. (A) There was no significant effect of HMW HA on total white blood cell (WBC) and neutrophil counts. However, HMW HA administration reduced the median level of TNFα (tumor necrosis factor α) in the BAL fluid (BALF) by 23% induced by E. coli pneumonia, although it was not statistically significant. Data are median with interquartile range, n = 6–10 per treatment group. *P < 0.05, **P < 0.01, and ****P < 0.0001 by Kruskal-Wallis with Dunn’s correction. P values and confidence intervals are shown in Table E1. (B) Although at individual time points there were statistically significant differences between groups, there appeared to be no overall effect of HMW HA administration on pulmonary arterial pressure, airway pressure, or Po₂ levels over time. Data are median with interquartile range, n = 6–10 per treatment group, P is significant versus corresponding group at each time point by Mann-Whitney test. PAP = pulmonary artery pressure.