Table 2.
Exposure-outcome cell counts observed in electronic health data source, not accounting for outcome misclassification | ||
Observed to have the outcome in data source | Observed to not have the outcome in data source | |
Exposed | ||
Unexposed | ||
Formula 1: Calculation of relative risk observed in electronic data in an analysis of electronic data, without consideration of outcome misclassification | ||
RR(Observed) = | ||
Corrected distribution of outcomes by exposure using positive and negative predictive values 20 | ||
With Outcome | Without Outcome | |
Exposed | (1-NPV1) | (1-NPV1)) |
Unexposed | (1-NPV0) | (1-NPV0)) |
Formula 2: Calculation of corrected relative risk following corrected distribution of outcomes by exposure | ||
RR(Corrected) = |
NPV0: negative predictive value among unexposed; NPV1: negative predictive value among exposed; PPV0: positive predictive value among unexposed; PPV1: positive predictive value among exposed; RR: relative risk.