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. 2019 Nov 15;30(24):2969–2984. doi: 10.1091/mbc.E19-05-0284

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© 2019 Liao, Tham, Liang, et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.

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FIGURE 3: — Snx31-KO urothelium loses fusiform vesicles and accumulates lipid droplets. TEM images showing (A) a typical normal bladder urothelial umbrella cell with normal mitochondria (m), apical uroplakin plaques (black arrows), fusiform vesicles (FVs); see (D) for a high-magnification view of FVs showing the plaques (arrow) and hinges (arrowhead). (B, C, E, and F) Superficial cells of the Snx31-KO bladder urothelium. Note the absence of typical plaques and FVs, and the accumulation of large LDs, some enclosed by a membranous structure (**) and some even larger, naked ones (***). Also note the accumulation of subapical small spherical vesicles (#). Scale bars = 0.2 µm in D; 1 µm in A, B, E, and F.