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. 2019 Nov 15;30(24):2969–2984. doi: 10.1091/mbc.E19-05-0284

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© 2019 Liao, Tham, Liang, et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.

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FIGURE 4: — Lipid droplets originate from the mitochondria (related to Supplemental Videos 1A and 2). TEM images showing (A) a normal mouse bladder urothelial umbrella cell with multivesicular bodies (MVBs) and mitochondria (m). (B, C) Initiation of LD formation (arrow) in mitochondrion (m). (D–K) Small LDs (*; “stage I” in morphologically recognizable mitochondria) in the intermembrane space surrounded by the inner membrane of the mitochondrial cristae (arrows; J2 is a tracing of the image in J1); arrows mark the cristae connected to the LDs. A larger, “stage II” LD (**) surrounded by a small amount of mitochondria (L) with strings of residual cristae (arrows), or (M) without any more recognizable cristae structures; M2 is a high-magnification view of the boxed area in M1 showing the presence of a double-layered mitochondrial membrane (arrows). (N) A tomographic video (see Supplemental Video SV1A) and (O) a serial block-face SEM 3D model (see Supplemental Video SV2) showing that the LDs are indeed intramitochondrial. Scale bars = 0.2 µm in B, G, H, J, L, and M; 0.5 µm in A, C, D, E, F, and K.