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Reagents and conditions: (i) 2-aminopyridine-3-methanol (for 15) or 2-aminopyridine-5-methanol (for 16), MeCN, NaHCO3, 90 °C, 18 h: 32–75%; (ii) MsCl, Et3N, THF, 0 °C, 4 h; (iii) Me2NH, THF, 0 °C – rt, 3 h, 60–89% for two steps; (iv) H2O2, Na2WO4·2H2O, AcOH, MeOH, rt, 3 h; (v) NH4OAc, melt, 120 °C, 3 h, 19–27% for two steps.
