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| Compound | R1 | PfPKG pIC50 | Pf HXI pEC50a | LLE | mLogD |
|---|---|---|---|---|---|
| 2 | – | 8.70 | 6.44 | 6.3 | 2.4 |
| 9 | H | 7.45 | nt | 5.8 | 1.7 |
| 10 |  |
7.36 | nt | 4.4 | 3.0 |
| 11 |  |
8.06 | 5.76 | 5.8 | 2.5 |
| 12 |  |
8.14 | 6.95 | 6.0 | 2.1 |
| 13 |  |
8.35 | 6.70 | 6.8 | 1.5 |
nt = not tested.
