Table 3.
Genes upregulated in tumors after treatment relative to pretreatment. Shown are the 25 genes with the greatest significant fold change.
| Gene | fold change | P |
|---|---|---|
| After limb infusion | ||
| TREM1 | 12.49 | 0.023 |
| CCL3L1 | 10.59 | 0.009 |
| CCL3 | 10.36 | 0.013 |
| TNFRSF10C | 9.27 | 0.004 |
| CXCL3 | 8.9 | 0.042 |
| TREM2 | 8.09 | 0.003 |
| CXCR2 | 7.72 | 0.030 |
| CCL18 | 7.59 | 0.046 |
| MARCO | 7.43 | 0.002 |
| CCL23 | 7.31 | 0.016 |
| CXCL2 | 7.17 | 0.029 |
| S100A12 | 7.05 | 0.047 |
| SLC11A1 | 7.04 | 0.027 |
| CXCL1 | 6.96 | 0.039 |
| S100A8 | 6.9 | 0.038 |
| LILRA5 | 5.7 | 0.025 |
| C9 | 5.28 | 0.006 |
| CCL4 | 5.03 | 0.027 |
| PLAUR | 5.03 | 0.041 |
| IRGM | 4.84 | 0.006 |
| CCRL2 | 4.84 | 0.017 |
| IL21R | 4.82 | 0.016 |
| IL3RA | 4.79 | 0.001 |
| CD70 | 4.77 | 0.010 |
| ITGAX | 4.76 | 0.032 |
| After limb infusion and ipilimumab | ||
| CHIT1 | 17.27 | 0.001 |
| CCL18 | 8.09 | 0.001 |
| GZMA | 7.35 | 0.001 |
| CXCR6 | 7.23 | 0.000 |
| LY9 | 6.8 | 0.002 |
| KLRC2 | 6.68 | 0.000 |
| GZMH | 6.39 | 0.001 |
| GZMK | 6.34 | 0.003 |
| CCL26 | 6.25 | 0.004 |
| CCL3 | 6.1 | 0.010 |
| TREM2 | 6.01 | 0.003 |
| CCL3L1 | 5.95 | 0.009 |
| PDCD1 | 5.73 | 0.011 |
| SH2D1A | 5.4 | 0.005 |
| KLRK1 | 5.39 | 0.001 |
| CD3G | 5.27 | 0.006 |
| CD2 | 5.26 | 0.009 |
| NCR1 | 4.97 | 0.001 |
| IFNG | 4.9 | 0.011 |
| KLRG1 | 4.89 | 0.005 |
| IL18RAP | 4.88 | 0.006 |
| CXCR3 | 4.88 | 0.019 |
| CCL5 | 4.87 | 0.003 |
| CD27 | 4.82 | 0.015 |
| ICOS | 4.81 | 0.010 |