Figure 5.

Schematic of hepatic transport model used. We consider five transport rates for fluorescein: k_{S → H} for the transport from the sinusoid to the hepatocyte, k_{H → S} from the hepatocyte back to the sinusoid, k_{H → C} from the hepatocyte to the canaliculus, and a loss rate k_C from the canaliculus. We also assume glucuronidated fluorescein is transported via the same mechanisms, albeit with rates that have different values, designated by the primed symbols above. Finally, k_HT represents the transformation of fluorescein into its glucuronidated form within the hepatocyte. The arrows show the direction of flow.