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. 2019 Nov 8;10:2632. doi: 10.3389/fimmu.2019.02632

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Copyright © 2019 Mountford, Ringleb, Schwaiger, Mayr, Kobold, Dinarello and Bufler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transgene IL-37 expression is associated with improved clinical outcome of chronic colitis in IL-10KO mice. Mild colitis was induced in IL-10KO/IL-37tg and IL-10KO mice which were scored in regards to (A) percent weight change (0: none, 1: −5%, 2: 5–10%, 3: 10–15%, 4: >15%), (B) blood in the stool (0: normal, 2: slight bleeding, 4: gross bleeding), (C) stool consistency (0: normal, 2: loose stool, 4: watery diarrhea) and (D) colon length (E) Overall disease activity: Clinical severity of colitis (stool consistency, weight loss and fecal blood) were recorded daily for the first 15 days and three times weekly thereafter (F) Overall survival. Open circles/bars: IL10KO (n = 10), closed circles/bars: IL-10KO/IL-37tg (n = 5). ^*p < 0.01. Statistical significance tested with Mann-Whitney-Test.