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. 2019 Nov 8;10:2632. doi: 10.3389/fimmu.2019.02632

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Copyright © 2019 Mountford, Ringleb, Schwaiger, Mayr, Kobold, Dinarello and Bufler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spontaneous cytokine release from colon biopsies. Transmural biopsies from macroscopically non-inflamed areas of the proximal colon were taken at the time of colon removal during chronic colitis and incubated in RPMI for 24 h. Supernatants were tested for spontaneous cytokine release. Cytokines were measured by multiplex array and Elisa (IL-6). Data are expressed as the mean (SEM). Open bars: IL-10KO mice (n = 10), closed bars: IL-10KO/IL-37tg mice (n = 5). ^*p < 0.05. Statistical significance tested with Mann-Whitney-Test.