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. 2019 Nov 8;10:2632. doi: 10.3389/fimmu.2019.02632

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Copyright © 2019 Mountford, Ringleb, Schwaiger, Mayr, Kobold, Dinarello and Bufler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced inflammation and colon carcinogenesis in IL-10KO/IL-37tg mice in the course of chronic colitis. Whole explanted colons from IL-10KO mice (A) and IL-10KO/IL-37tg mice (B) were rolled up from distal to proximal (“swiss role”), transferred to formaldehyde solution for 24 h and subsequently embedded in paraffin. Cross-sections of full-length bowel specimen underwent HE-staining (A–F). (C) Ulceration and high-grade inflammation of IL-10KO mouse. (D) Low-grade infiltration IL-10KO/IL-37tg. (E) Regenerative Hyperplasia with high-grade inflammation in IL-10KO mice. (F) Mild- infiltration in IL-10KO/IL-37tg mouse. Cross-sections of full-length bowel specimen underwent Ki-67-staining (G,H). PT2 carcinoma in IL-10KO mouse (G,I). Healthy tissue of IL-10KO/IL-37tg mouse (H,J).