Table 1.
Characteristics of study population at baselinea and at last clinic visit for total population, and cohorts meeting IeDEA and 365-day loss to follow-up criteria.
| Total population N=3,509 |
IeDEA LTFU cohort N=275 |
365-day absence LTFU cohort N=149 |
||||
|---|---|---|---|---|---|---|
| Baselinea | Last visit | Baselinea | Last visit | Baselinea | Last visit | |
| Median age (years) [range] | 10 [10,18.9] | 15.7 [10.0, 20.0] | 10 [10, 16.0] | 15.5 [10.1, 19.5] | 10 [10, 15.0] | 15.5 [10.1, 18.8] |
| Median period between baseline and last visit (years) [IQR] | 5.3 [3.2, 7.8] | 5.0 [2.8, 7.0] | 5.0 [2.7, 6.6] | |||
| Sex | ||||||
| Male | 1,731 (49.3) | 145 (52.7) | 79 (53.0) | |||
| Country | ||||||
| Cambodia | 549 (15.7) | 32 (11.6) | 21 (14.1) | |||
| India | 162 (4.6) | 32 (11.6) | 27 (18.1) | |||
| Indonesia | 125 (3.6) | 15 (5.5) | 6 (4.0) | |||
| Malaysia | 257 (7.3) | 33 (12.0) | 15 (10.1) | |||
| Thailand | 1,592 (45.4) | 148 (53.8) | 67 (45.0) | |||
| Vietnam | 824 (23.5) | 15 (5.5) | 13 (8.7) | |||
| Clinic setting | ||||||
| Urban | 1,935 (55.1) | 151 (54.9) | 64 (43.0) | |||
| Semi-urban | 1,360 (38.8) | 86 (31.3) | 55 (36.9) | |||
| Rural | 214 (6.1) | 38 (13.8) | 30 (20.1) | |||
| Calendar period at enrolment in care | ||||||
| <2002 | 326 (9.3) | 29 (10.6) | 20 (13.4) | |||
| 2002–2006 | 1,615 (46.0) | 129 (46.9) | 76 (51.0) | |||
| 2007–2011 | 1,303 (37.1) | 88 (32.0) | 42 (28.2) | |||
| 2012–2016 | 265 (7.6) | 29 (10.6) | 11 (7.4) | |||
| Orphan | ||||||
| No | 2,449 (69.8) | 2,395 (68.3) | 184 (66.9) | 178 (64.7) | 97 (65.1) | 95 (63.8) |
| Yes | 800 (22.8) | 854 (24.3) | 65 (23.6) | 71 (25.8) | 38 (25.6) | 40 (26.9) |
| Missing/unknown | 260 (7.4) | 260 (7.4) | 26 (9.5) | 26 (9.5) | 14 (9.4) | 14 (9.4) |
| Primary caregiver | ||||||
| Immediate family | 1,369 (39.0) | 1,643 (46.8) | 93 (33.8) | 122 (44.4) | 42 (28.2) | 67 (45.0) |
| Extended family | 834 (23.8) | 1,230 (35.1) | 68 (24.7) | 95 (34.6) | 34 (22.8) | 49 (32.9) |
| Foster care | 292 (8.3) | 389 (11.1) | 35 (12.7) | 45 (16.4) | 19 (12.8) | 22 (14.8) |
| Missing/unknown | 1,014 (28.9) | 247 (7.0) | 79 (28.7) | 13 (4.7) | 54 (36.2) | 11 (7.4) |
| CD4 count (cells/μL)b | ||||||
| Median [IQR] | 700 [416, 977] | 644 [447, 860] | 737 [482, 1002] | 627 [427, 861] | 707 [417, 965] | 560 [333, 778] |
| ≥500 | 2,101 (59.9) | 1,896 (54.0) | 171 (62.2) | 150 {54.6) | 87 (58.4) | 65 (43.6) |
| 350–499 | 319 (9.1) | 394 (11.2) | 21 (7.6) | 28 (10.2) | 11 (7.4) | 21 (14.1) |
| 200–349 | 233 (6.6) | 218 (6.2) | 17 (6.2) | 24 (8.7) | 12 (8.1) | 17 (11.4) |
| <200 | 407 (11.6) | 246 (7.0) | 24 (8.7) | 22 (8.0) | 12 (8.1) | 14 (9.4) |
| Missing/unknown | 449 (12.8) | 755 (21.5) | 42 (15.3) | 51 (18.6) | 27 (18.1) | 32 (21.5) |
| Viral load (copies/mL)b | ||||||
| Median log [IQR]c | 4.0 [2.7, 4.9] | 3.5 [2.1, 4.7] | 3.5 [2.2, 4.8] | 3.9 [2.4, 4.7] | 3.5 [2.5, 4.9] | 4.3 [3.1, 4.7] |
| Undetectable | 1,205 (34.3) | 1,866 (53.2) | 125 (45.5) | 120 (43.6) | 55 (36.9) | 48 (32.2) |
| Detectable <1,000 | 182 (5.2) | 254 (7.2) | 17 (6.2) | 19 (6.9) | 8 (5.4) | 7 (4.7) |
| 1,000–9,999 | 110 (3.1) | 121 (3.5) | 9 (3.3) | 15 (5.5) | 5 (3.4) | 10 (6.7) |
| ≥10,000 | 300 (8.6) | 252 (7.2) | 17 (6.2) | 29 (10.6) | 9 (6.0) | 18 (12.1) |
| Missing/unknown | 1,712 (48.8) | 1,016 (29.0) | 107 (38.9) | 92 (33.5) | 72 (48.3) | 66 (44.3) |
| WHO clinical stageb | ||||||
| I/II | 3,252 (92.7) | 3,431 (97.8) | 252 (91.6) | 267 (97.1) | 13 (92.0) | 145 (97.3) |
| III/IV | 257 (7.3) | 78 (2.2) | 23 (8.4) | 8 (2.9) | 12 (8.1) | 4 (2.7) |
| Age at cART initiation (years) | ||||||
| Median [IQR] | 7.0 [4.4, 9.8] | 6.8 [4.0, 9.4] | 7.4 [5.0, 10.3] | |||
| <5 | 1,048 (29.9) | 91 (33.1) | 38 (25.5) | |||
| 5–9 | 1,655 (47.2) | 129 (46.9) | 70 (47.0) | |||
| ≥10 | 806 (23.0) | 55 (20.0) | 41 (27.5) | |||
| cART regimens | ||||||
| 0 | 625 (17.8) | 0 | 43 (15.6) | 0 | 33 (22.2) | 0 |
| 1 | 2,385 (68.0) | 2,490 (71.0) | 181 (65.8) | 177 (64.4) | 91 (61.1) | 101 (67.8) |
| ≥2 | 499 (14.2) | 1,019 (29.0) | 51 (18.6) | 98 (35.6) | 25 (16.8) | 48 (32.2) |
Values n (%) unless otherwise specified.
a
Either 10th birthday or first clinic visit if after 10th birthday.
b
Most recent value within prior 365 days.
c
Calculated only for detectable HIV viral loads.
cART = combination antiretroviral therapy. IeDEA = International epidemiology Databases to Evaluate AIDS. LTFU = loss to follow-up. WHO = World Health Organization.