Table 2.
Characteristics associated with loss to follow-up for IeDEA and 365-day absence criteria.
| IeDEA LTFU | 365-day absence LTFU | |||
|---|---|---|---|---|
| aSHR [95%CI] | p | aSHR [95%CI] | p | |
| Age (years) | ||||
| 10–14 | 1.0 | 1.0 | ||
| 15–19 | 0.6 [0.2, 1.4] | 0.23 | 0.2 [0.1, 0.5] | <0.001 |
| Sex | ||||
| Male | 1.0 | 1.0 | ||
| Female | 0.8 [0.6, 1.0] | 0.09 | 0.8 [0.5, 1.1] | 0.13 |
| Clinic setting | ||||
| Urban | 1.0 | 1.0 | ||
| Semi-rural | 0.8 [0.6, 1.1] | 0.14 | 1.1 [0.8, 1.7] | 0.50 |
| Rural | 1.9 [1.2, 3.1] | 0.01 | 3.0 [1.6, 5.5] | <0.001 |
| Orphan | ||||
| No | NS | NS | ||
| Yes | NS | NS | ||
| Primary carer | ||||
| Immediate family | 1.0 | 1.0 | ||
| Extended family | 0.9 [0.7, 1.3] | 0.60 | 0.9 [0.6, 1.4] | 0.64 |
| Foster care | 1.3 [0.9, 1.8] | 0.21 | 1.4 [0.8, 2.3] | 0.23 |
| Age at cART initiation | ||||
| <5 years | 1.0 | 1.0 | ||
| 5–9 years | 0.4 [0.3, 0.6] | <0.001 | 0.5 [0.3, 0.8] | 0.002 |
| ≥10 years | 0.3 [0.2, 0.4] | <0.001 | 0.5 [0.3, 0.8] | 0.003 |
| cART regimens | ||||
| 1 | 1.0 | NS | ||
| ≥2 | 1.1 [0.8, 1.4] | 0.65 | NS | |
| CD4 count (cells/μL) | ||||
| ≥500 | 1.0 | 1.0 | ||
| 350–499 | 0.9 [0.6, 1.4] | 0.74 | 1.6 [1.0, 2.5] | 0.05 |
| 200–349 | 1.1 [0.7, 1.8] | 0.78 | 1.2 [0.7, 2.4] | 0.50 |
| <200 | 0.8 [0.5, 1.5] | 0.49 | 0.8 [0.3, 1.9] | 0.60 |
| HIV viral load (copies/mL) | ||||
| Undetectable | 1.0 | 1.0 | ||
| Detectable <1,000 | 1.2 [0.8, 1.8] | 0.41 | 1.3 [0.7, 2.4] | 0.44 |
| 1,000–9,999 | 1.5 [0.9, 2.5] | 0.09 | 2.4 [1.3, 4.2] | 0.003 |
| ≥10,000 | 1.9 [1.4, 2.7] | <0.001 | 2.3 [1.5, 3.8] | <0.001 |
| WHO clinical stage | ||||
| I/II | NS | NS | NS | |
| III/IV | NS | NS | NS | |
aSHR = adjusted subdistribution hazard ratio. cART = combination antiretroviral therapy. CI = confidence interval. IeDEA = International epidemiology Databases to Evaluate AIDS. LTFU = loss to follow-up. NS = not significant on univariate analysis. WHO = World Health Organization.